Chronic Conditions
Primary Immunodeficiency
Living with Primary Immunodeficiency is a challenge. Let TwelveStone make life easier with a care team built around you to manage your chronic condition.Primary Immunodeficiency Medications
If you’ve been diagnosed with a primary immunodeficiency, TwelveStone Health Partners provides specialized infusion care designed around your treatment plan. Our clinical team administers immunoglobulin replacement therapy (IVIG or SCIG) based on your diagnosis, infection history, and laboratory results to help support long-term immune health.
Backed by more than 35 years of pharmacy experience and over 30 private infusion locations, our PharmD-led team provides expert clinical oversight in comfortable infusion suites designed to make every visit as convenient as possible. Patients receive treatment in a private setting with WiFi, television, and refreshments.
Ashley Mcgee
Absolutely loved this place amazing staff and made you feel well taken care of! Would give more than 5 if I could on the stars! 🩷⭐️⭐️⭐️⭐️
David Brandes
Ronetta Witherspoon
Mandy Leitsch
Kay Duncan
Hardly no waiting, awesome nurses. A good place to have to go get infusions.
Robert Holloway
Minnie Toler
They were so welcoming and caring.They had a whiteboard with a greeting and personal welcome from their staff. They also always made sure that I was always comfortable.
Maurice Carter
I've been twice so far for my monthly injection. These are the kindest, nicest, most pleasant people! But also quick and efficient. I was in and out in less than 10 minutes this week.
Ashley Mondesir
I had an absolutely incredible experience at Twelvestone in Smyrna. Loraine, Leah, and Leoneed were fantastic. All so caring, patient, and attentive. I have had a longtime fear of needles but knowing I will have the support of such a lovely team with those incredible women when I come in for infusions will put me at such ease. Fantastic team!
Marion Jones
Domitila Craighead
I have been using Twelve Stone for almost three years now. The staff is very caring and always trying to make the experience as pleasant as possible. They are always willing to answer any questions you may have and do everything to make you comfortable
Tiffany Smith
catherine jameson
Nice comfortable atmosphere. The staff was very proficient, knowledgeable and friendly and made me feel very comfortable In spite of my nervousness and apprehension of getting the infusion. Thanks for your professionalism.
Catherine Jameson
KentuckyGuy
Very professional and kind staff. Sadly, I’ve had to use them twice now. If you end up at TwelveStone know that you are in good hands.
A Williams
We had a very pleasant and relaxing experience at TwelveStone Infusion center today for my mom’s treatment! Everyone in the office was extremely nice and welcoming. We really felt at home there and the snacks were a huge blessing! Thank you Jessica, Sarah and Megan, y’all are amazing!! And Jennifer at the front, we appreciate your kindness and helpful heart!
Terri Gamble
Great experience at Twelvestone Infusion center. Great location. The facility was clean, individual rooms made me comfortable while getting my infusion. The. . receptionist to nurses were friendly and efficient. Highly recommend using them.
Vk Reece
Sarah and Stacy were jewels. It started at the Reception desk and in the infusion room. Everything went Exceptionally well. THANK YOU ❣️
Sky Stephens
I would recommend this facility to everyone. Ms Chelsea and Ms Jordan were so helpful. These ladies are amazing... Thank you for taking care of my dad.... 100% And 5 Stars for me
Rachel McClure
Even though I go there for treatment, I always enjoy going. That bunch there is like family. I’ve never been to any other place that makes each patient feel so special. Highly recommend Twelve Stone in Murfreesboro Tn.
Charmayne Calhoun
They always have the best nurses and practitioners there. The front office lady is really nice. I like how they run a "tight schedule" in the most respectful way. Making sure all scheduled patients are seen on time. Great facility to get your infusions from.
Charmaine Williams
Rachel Lee
This is a wonderful place to get your infusions done. The staff are very friendly and welcoming and very knowledgeable with their nursing care. The facility is very home-like and comforting. Their God centered environment practice was refreshing to see. I 10/10 recommend.
Sue Hirsbrunner
Everyone was so kind and helpful. My nurses were Meagan and Stephanie. They were both very helpful. It was very interesting and I really liked the facility and especially my nurse Stephanie.
Norma Velasco
Everyone at this facility very pleasant and informative. So glad my Physican referred me to this location. See
Leigh Tribble
While one would hope that you would never have to go to a facility of this nature, I can say with complete honesty that we felt nothing but empathy, kindness and heartfelt care at this infusion center. Absolutely the most professional and kind medical facility and staff we have encountered.
Understanding Primary Immunodeficiency and Your Symptoms
Primary immunodeficiency is a group of inherited disorders that prevent the immune system from functioning properly, making it harder for the body to fight common infections. Unlike immune deficiencies caused by chemotherapy, cancer treatment, or certain medications, these conditions are genetic and often require ongoing specialty care. Early diagnosis and appropriate treatment can help reduce infections and improve quality of life.
Common signs and symptoms that may prompt an evaluation by an immunologist include:
- Frequent sinus or ear infections that return quickly after treatment
- Multiple bouts of pneumonia or bronchitis within a single year
- Infections that require consecutive courses of antibiotics to clear
- Chronic digestive issues or poor physical growth in children
While internet searches often present worst-case scenarios, a professional diagnosis is straightforward. An immunologist confirms the condition using your clinical history alongside detailed laboratory blood tests that measure specific antibody levels.
If a deficiency is found, immunoglobulin replacement therapy serves as a standard primary immunodeficiency treatment to help your body defend itself and prevent future illness.
Immunoglobulin Replacement Therapy: IVIG vs. SCIG Options
Once primary immunodeficiency has been diagnosed, immunoglobulin replacement therapy becomes a long-term treatment option for many patients. If your body cannot produce enough protective antibodies, your immunologist may recommend IVIG or SCIG therapy to help reduce infections and support long-term immune function. The right treatment approach depends on your diagnosis, medical history, and lifestyle.
Comparing IVIG and SCIG Options
Intravenous immunoglobulin (IVIG) is typically administered every three to four weeks in larger doses. While this schedule requires fewer infusion visits, some patients may experience temporary side effects such as headaches because antibody levels naturally rise and fall between treatments.
Subcutaneous immunoglobulin (SCIG) is administered in smaller weekly or biweekly doses. Because antibody levels remain more consistent over time, many patients experience fewer systemic side effects, although mild redness or irritation at the injection site can occur.
Your immunologist will recommend the treatment method and dosing schedule that best fits your condition and lifestyle. Throughout therapy, the clinical team monitors your response, adjusts treatment when appropriate, and works closely with your prescribing physician to support safe, effective care. Immunoglobulin therapy is also prescribed for several autoimmune and neurological conditions, including myasthenia gravis.
Your Immunoglobulin Infusion: What to Expect from Start to Finish
TwelveStone provides immune globulin infusion therapy for patients receiving primary immunodeficiency treatment at private infusion centers throughout the Southeast. For eligible patients, home infusion may also be available. Our team coordinates scheduling, clinical care, and insurance requirements so you can focus on your health instead of the logistics of treatment.
To improve comfort during treatment, clinicians may adjust infusion rates or recommend appropriate pre-medications based on your medical history. If your care needs change over time, our team can also coordinate additional infusion therapies or help transition eligible patients to enteral or home infusion services.
Our team manages prior authorizations, verifies insurance benefits, and helps patients navigate available copay assistance programs whenever possible. To get started, request an appointment online or contact our clinical team to discuss your treatment plan.
Begin Your Primary Immunodeficiency Treatment Journey in the Southeast
Whether you’re beginning treatment or transitioning your infusion care, TwelveStone Health Partners is here to support every step of your primary immunodeficiency treatment journey. From benefits verification and prior authorizations to ongoing infusion therapy, our clinical team helps simplify the process while delivering personalized care in a comfortable, private setting. Request an appointment today to speak with our team and begin your treatment plan.
Organizational Resources
The Immune Deficiency Foundation improves the diagnosis, treatment, and quality of life for every person affected by primary immunodeficiency.
The Foundation for Primary Immunodeficiency (FPID) supports education, early diagnosis, genetic counseling, therapy, and research of the disease in the U.S. and India.
The Jeffrey Modell Foundation (JMF) is a global, nonprofit patient organization devoted to early and precise diagnosis, meaningful treatments, and ultimately, cures – through clinical and basic research, physician education, patient support, advocacy, public awareness, and newborn screening.
New Patient Resources
Healthcare Costs
- Patient Assistance Programs
- Cost Drivers of Primary Immunodeficiency
- Healthcare Cost Assistance
