Chronic Conditions
Neuromyelitis Optica Spectrum Disorder
Living with NOSD is a challenge. Let TwelveStone make life easier with a care team built around you to support life with a chronic condition.Neuromyelitis Optica Spectrum Disorder Medications
TwelveStone Health Partners provides specialized care coordination and infusion services for patients who have been prescribed biologic therapy for neuromyelitis optica spectrum disorder (NMOSD) at 30+ regional locations. Working alongside your prescribing neurologist, our clinical team supports your prescribed relapse-prevention therapy through medication administration, monitoring, and coordinated care.
Our team supports the key logistics around your prescribed therapy, including benefits verification, prior authorization, copay assistance resources, and scheduling. Contact us to start the intake process and learn what information we need to coordinate your prescribed treatment.
Ashley Mcgee
Absolutely loved this place amazing staff and made you feel well taken care of! Would give more than 5 if I could on the stars! 🩷⭐️⭐️⭐️⭐️
David Brandes
Ronetta Witherspoon
Mandy Leitsch
Kay Duncan
Hardly no waiting, awesome nurses. A good place to have to go get infusions.
Robert Holloway
Minnie Toler
They were so welcoming and caring.They had a whiteboard with a greeting and personal welcome from their staff. They also always made sure that I was always comfortable.
Maurice Carter
I've been twice so far for my monthly injection. These are the kindest, nicest, most pleasant people! But also quick and efficient. I was in and out in less than 10 minutes this week.
Ashley Mondesir
I had an absolutely incredible experience at Twelvestone in Smyrna. Loraine, Leah, and Leoneed were fantastic. All so caring, patient, and attentive. I have had a longtime fear of needles but knowing I will have the support of such a lovely team with those incredible women when I come in for infusions will put me at such ease. Fantastic team!
Marion Jones
Domitila Craighead
I have been using Twelve Stone for almost three years now. The staff is very caring and always trying to make the experience as pleasant as possible. They are always willing to answer any questions you may have and do everything to make you comfortable
Tiffany Smith
catherine jameson
Nice comfortable atmosphere. The staff was very proficient, knowledgeable and friendly and made me feel very comfortable In spite of my nervousness and apprehension of getting the infusion. Thanks for your professionalism.
Catherine Jameson
KentuckyGuy
Very professional and kind staff. Sadly, I’ve had to use them twice now. If you end up at TwelveStone know that you are in good hands.
A Williams
We had a very pleasant and relaxing experience at TwelveStone Infusion center today for my mom’s treatment! Everyone in the office was extremely nice and welcoming. We really felt at home there and the snacks were a huge blessing! Thank you Jessica, Sarah and Megan, y’all are amazing!! And Jennifer at the front, we appreciate your kindness and helpful heart!
Terri Gamble
Great experience at Twelvestone Infusion center. Great location. The facility was clean, individual rooms made me comfortable while getting my infusion. The. . receptionist to nurses were friendly and efficient. Highly recommend using them.
Vk Reece
Sarah and Stacy were jewels. It started at the Reception desk and in the infusion room. Everything went Exceptionally well. THANK YOU ❣️
Sky Stephens
I would recommend this facility to everyone. Ms Chelsea and Ms Jordan were so helpful. These ladies are amazing... Thank you for taking care of my dad.... 100% And 5 Stars for me
Rachel McClure
Even though I go there for treatment, I always enjoy going. That bunch there is like family. I’ve never been to any other place that makes each patient feel so special. Highly recommend Twelve Stone in Murfreesboro Tn.
Charmayne Calhoun
They always have the best nurses and practitioners there. The front office lady is really nice. I like how they run a "tight schedule" in the most respectful way. Making sure all scheduled patients are seen on time. Great facility to get your infusions from.
Charmaine Williams
Rachel Lee
This is a wonderful place to get your infusions done. The staff are very friendly and welcoming and very knowledgeable with their nursing care. The facility is very home-like and comforting. Their God centered environment practice was refreshing to see. I 10/10 recommend.
Sue Hirsbrunner
Everyone was so kind and helpful. My nurses were Meagan and Stephanie. They were both very helpful. It was very interesting and I really liked the facility and especially my nurse Stephanie.
Norma Velasco
Everyone at this facility very pleasant and informative. So glad my Physican referred me to this location. See
Leigh Tribble
While one would hope that you would never have to go to a facility of this nature, I can say with complete honesty that we felt nothing but empathy, kindness and heartfelt care at this infusion center. Absolutely the most professional and kind medical facility and staff we have encountered.
Where Infusion Therapy Fits in NMOSD Relapse Prevention
NMOSD is an autoimmune disorder that most often affects the optic nerves and spinal cord. Relapses can cause vision loss, weakness, numbness, and other neurologic symptoms, and repeated attacks may lead to lasting disability. For that reason, preventing future relapses is a major goal of long-term NMOSD treatment.
NMOSD care includes treating acute attacks and reducing the risk of future relapses. Acute attacks are managed by a neurology or emergency care team and may involve treatments such as high-dose corticosteroids or plasma exchange. TwelveStone supports the outpatient phase after your neurologist prescribes a relapse-prevention therapy, including infusion administration and treatment coordination when appropriate.
Your neurologist may use AQP4-IgG testing, MRI findings, and your clinical history to help diagnose NMOSD and distinguish it from conditions with overlapping features, including multiple sclerosis and MOG antibody-associated disease (MOGAD). AQP4-IgG status also affects treatment eligibility because FDA-approved targeted NMOSD therapies are indicated for adults who are AQP4-antibody positive. Your neurologist will determine which therapy is appropriate for your individual condition.
Once your neurologist prescribes a therapy that TwelveStone can support, our team can help verify benefits, coordinate authorization, and schedule treatment at an appropriate location. Contact us to confirm medication and location availability and begin the intake process.
FDA-Approved NMOSD Biologics: Infusion and Injection Options
Four targeted biologic therapies are FDA-approved in the United States for adults with NMOSD who are anti-AQP4 antibody positive: eculizumab, ravulizumab, inebilizumab, and satralizumab. They work through different immune pathways and are administered either by intravenous infusion or subcutaneous injection. Your neurologist will determine which option is appropriate based on your medical history, treatment goals, dosing schedule, safety considerations, and other individual factors.
| Treatment Approach | Infusion or Injection Option |
|---|---|
| Complement C5 inhibitors | Eculizumab (Soliris) and ravulizumab (Ultomiris) are administered by intravenous infusion for NMOSD. Because these medications increase the risk of serious meningococcal infection, patients must follow meningococcal vaccination requirements, and prescribers must comply with the ULTOMIRIS and SOLIRIS REMS program. |
| B-cell depletion | Inebilizumab (Uplizna) is administered by intravenous infusion. Treatment begins with two initial doses two weeks apart, followed by maintenance infusions every six months as prescribed. TwelveStone provides Uplizna infusion care for eligible adults with NMOSD and coordinates treatment with the prescribing physician. |
| IL-6 receptor blockade | Satralizumab (Enspryng) is administered as a subcutaneous injection. After appropriate training from a healthcare professional, eligible patients or caregivers may administer the medication at home according to the prescribed schedule. |
Rituximab is also used off-label for some patients with NMOSD, although it is not FDA-approved specifically for this condition. Decisions about continuing rituximab or changing to another preventive therapy should be made with your neurologist based on your individual clinical needs.
For infusion therapies supported by TwelveStone, our team works with your prescribing office on referral intake, benefits verification, prior authorization, scheduling, and clinical administration.
What to Expect During Your Infusion Visit
Your visit at a TwelveStone infusion center follows a structured process that may vary depending on your prescribed medication and treatment plan. Care is provided in a private treatment suite, with clinical monitoring throughout the infusion and amenities such as Wi-Fi, television, and refreshments available at participating locations.
- Check-in and assessment: Your care team confirms your treatment information, reviews relevant health updates, and records baseline vital signs before the infusion begins.
- IV or access placement: A licensed clinical team member establishes IV access or uses an appropriate existing access device, depending on your treatment order.
- Pre-medications, when required: Depending on your prescribed therapy, your treatment plan may include medications given before the infusion to help reduce the risk or severity of infusion-related reactions.
- Infusion and monitoring: Your prescribed medication is administered according to its ordered infusion rate while the clinical team monitors you throughout treatment.
- Post-infusion observation: Depending on the medication and your treatment protocol, you may remain at the center for monitoring after the infusion is complete.
- Discharge instructions: Before you leave, your care team reviews any medication-specific precautions, follow-up instructions, and symptoms that should prompt you to contact your provider or seek urgent medical care.
Before your appointment, follow any preparation instructions provided for your specific medication. Unless your care team advises otherwise, staying well hydrated may make IV placement easier, and comfortable clothing with loose or adjustable sleeves can help with access.
You may also bring a book, headphones, or another activity for longer visits. If your care team tells you that a pre-medication may cause drowsiness, arrange transportation home in advance.
After treatment, follow the discharge instructions provided by your clinical team and report new or concerning symptoms as directed. Contact TwelveStone before your appointment if you have questions about preparation, visit length, or what to expect with your prescribed therapy.
Your Path to NMOSD Infusion Care
Once your neurologist prescribes an infusion therapy that TwelveStone supports, our team helps coordinate the steps between referral and treatment. We work with you, your prescribing provider, and your insurer to manage applicable authorization, medication, and scheduling requirements while supporting the treatment plan ordered by your neurologist.
Our care coordination team can assist with the key steps required to get your prescribed infusion scheduled:
TwelveStone operates 30+ infusion centers across the Southeast, giving patients multiple options for community-based treatment. Medication safety is supported by PharmD professionals and experienced infusion clinicians, with care coordinated alongside your prescribing provider.
Organizational Resources
The Guthy-
Jackson Charitable Foundation
is a voluntary, non-profit organization dedicated to funding basic and clinical research needed to treat and cure Neuromyelitis Optica (NMO).
The Sumaira Foundation is a 501(c)(3) organization dedicated to generating global awareness of NMOSD and MOGAD, building communities of support for patients and their caregivers, supporting research and patient advocacy.
The National Multiple Sclerosis Society is a nonprofit organization dedicated to supporting individuals affected by multiple sclerosis and funding research to find a cure for the disease
New Patient Resources
Ready to begin? When you contact TwelveStone, have your insurance information and any available details about your prescribing provider and ordered medication nearby. Our team can explain what additional information or documentation is needed to move your referral forward.
Common Questions About NMOSD Infusion Therapy
If you have a prescribed infusion therapy and need help with referral, insurance verification, authorization, or scheduling, contact TwelveStone Health Partners to speak with a care coordinator.
