Imaavy
TwelveStone Health Partners provides Imaavy infusion treatment for adults and patients ages 12 and older with generalized myasthenia gravis who are positive for anti-AChR or anti-MuSK antibodies. Our infusion teams coordinate with your prescribing neurologist to support treatment in a professionally monitored outpatient setting.
From referral through each infusion visit, our team helps coordinate scheduling, insurance requirements, and communication with your prescribing provider. Treatment takes place in private infusion suites with professional clinical monitoring and amenities designed to make your time at the center more comfortable.
Contact our care team to discuss your Imaavy referral and scheduling
How Imaavy Infusion Treatment Works for gMG
Generalized myasthenia gravis (gMG) is an autoimmune neuromuscular condition in which certain antibodies interfere with communication between nerves and muscles. Imaavy is approved for patients ages 12 and older whose gMG is associated with anti-AChR or anti-MuSK antibodies.
How Imaavy Targets IgG Autoantibodies
Imaavy (nipocalimab-aahu) is an FcRn blocker that reduces circulating IgG antibodies, including the autoantibodies associated with gMG. By blocking the neonatal Fc receptor, Imaavy increases the clearance of IgG from the bloodstream, reducing the antibodies that can interfere with nerve-to-muscle communication.
By lowering these circulating antibodies, Imaavy is designed to address an underlying immune mechanism involved in gMG. Your neurologist can explain how this mechanism relates to your symptoms, treatment goals, and other therapies in your care plan.
Imaavy Infusion Schedule: What to Expect
Imaavy follows a scheduled intravenous dosing regimen. Treatment begins with an initial dose, followed two weeks later by maintenance infusions every two weeks. The medication administration time differs between the initial and maintenance doses.
| Treatment Stage | Recommended Dose | Minimum Infusion Time | Timing |
|---|---|---|---|
| Initial infusion | 30 mg/kg IV | At least 30 minutes | Once at the start of treatment |
| Maintenance infusions | 15 mg/kg IV | At least 15 minutes | Beginning two weeks later and continuing every two weeks |
| Post-infusion monitoring | — | 30 minutes | After every infusion |
Your total appointment will take longer than the medication infusion itself because time is also needed for check-in, clinical preparation, IV placement, and post-infusion monitoring.
Although each visit may vary based on your prescribed treatment plan and clinical needs, a typical appointment includes the following:
- Before Your Visit: Follow any instructions provided by your care team, arrive well hydrated unless your provider has advised otherwise, and bring your photo ID, insurance information, and current medication list. Comfortable layers and a personal device can also help during your visit.
- Pre-Infusion Assessment: Your clinical team checks your vital signs and reviews any current symptoms or health changes that could affect treatment. Tell your care team if you have signs or symptoms of an infection before your infusion.
- Infusion Administration: A member of your clinical team places or accesses your IV and administers Imaavy while you receive care in a private treatment suite.
- Post-Infusion Observation: Your clinical team monitors you for 30 minutes after each infusion for signs or symptoms of hypersensitivity or an infusion-related reaction.
Imaavy infusions at TwelveStone are provided in private treatment suites with personal recliners, high-speed Wi-Fi, and refreshments. Your clinical team monitors you throughout treatment and coordinates with your prescribing provider as needed. For patients who would like spiritual support, chaplain services are also available upon request.
How to Start Imaavy Treatment at TwelveStone
To begin Imaavy infusions at TwelveStone, your prescribing neurologist or specialist sends our team the treatment order or referral and supporting clinical records. Our intake team then works with your provider’s office to gather the information needed for insurance review and treatment scheduling.
Our financial counselors verify your insurance benefits and manage prior authorization requirements before treatment begins. Because coverage requirements vary by plan, the process may include the following steps:
- Benefits Verification: Confirming your plan’s coverage requirements for Imaavy.
- Prior Authorization: Coordinating the clinical documentation requested by your insurance plan and prescribing provider.
- Financial Assistance: Identifying available manufacturer copay or support programs for eligible patients.
- Scheduling: Coordinating your first infusion once the required clinical and insurance steps are complete.
Your prescribing neurologist determines which gMG therapy is appropriate for your individual treatment plan. If you are researching other medications administered through TwelveStone, you can learn about Vyvgart or explore our complete infusion treatment directory. Once Imaavy has been prescribed, our team can help coordinate the referral, insurance review, and scheduling process.
Frequently Asked Questions About Imaavy Infusion Treatment
Ready to begin the coordination process? TwelveStone can help with your Imaavy referral, insurance verification, care transfer, and scheduling once the necessary clinical and coverage requirements are in place.
