Entyvio® infusion therapy is a biologic treatment used to help control inflammation caused by Crohn’s disease and ulcerative colitis. At TwelveStone Health Partners, patients receive this treatment in a comfortable outpatient setting under the supervision of experienced clinical teams. Our infusion centers serve patients across Tennessee, Kentucky, Georgia, Mississippi, and Virginia.

Our experienced clinical teams provide medical oversight while assisting with insurance navigation and prior authorizations to ensure affordable access. Providers may initiate a referral for eligible patients, and patients or caregivers can request scheduling support at any of our regional locations.

Download the Entyvio® Referral Form

Infusion Care and Support

  • 35+ Years of Experience: Rooted in community pharmacy and specialty healthcare since the late 1980s.
  • 30+ Regional Locations: Centers throughout TN, KY, GA, MS, and VA.
  • Outpatient Care Model: Private suites providing a comfortable alternative to hospital settings.
  • Insurance Support: Assistance with benefits verification and prior authorizations.
  • Expert Clinical Team: Led by registered nurses and pharmacists.

Clinician wearing blue gloves starts an IV line in a patient’s arm for infusion treatment in a clean medical clinic setting.

What Is Entyvio® Infusion Therapy?

Entyvio (vedolizumab) is a prescription biologic for adults with moderate to severe ulcerative colitis or Crohn’s disease. Specialists often prescribe an Entyvio® Infusion Treatment when standard therapies fail to provide adequate relief. Unlike treatments that suppress the entire immune system, this medication uses a gut-selective mechanism to target inflammation specifically within the digestive tract.

These inflammatory bowel diseases involve the immune system attacking healthy gut tissue, causing persistent symptoms that often require biologic intervention. Common indicators include:

  • Abdominal pain and cramping
  • Frequent diarrhea or urgency
  • Chronic fatigue
  • Unexplained weight loss
  • Blood in the stool

Your gastroenterologist manages all treatment and dosing decisions. TwelveStone focuses on the clinical administration of your prescribed plan, coordinating directly with your referring office to manage your schedule. Our staff monitors each session in a professional outpatient environment, ensuring your care stays consistent between your specialist’s office and our infusion center.

What to Expect During Entyvio Administration

Entyvio is administered as an IV infusion within a professional outpatient infusion center. Most patients begin with an induction schedule at weeks 0, 2, and 6. Following this initial phase, maintenance infusions follow every eight weeks. Your gastroenterologist determines the exact frequency based on your clinical response and condition.

Schedule Your Entyvio Infusion. Our team helps coordinate referrals, insurance verification, and scheduling at a nearby TwelveStone infusion center.

Clinical Process and Monitoring

The infusion itself generally lasts about 30 minutes, though you should plan for additional time for check-in, IV placement, and a brief observation period. Our clinical staff monitors you throughout the appointment for any signs of hypersensitivity or infusion reactions. You should notify the nursing team immediately if you notice any new symptoms.

Preparation helps your appointment go smoothly. Arrive well-hydrated and wear loose sleeves that allow easy access for the IV. Bring your identification, insurance information, and a book or tablet to stay occupied during the visit.

Some patients experience fatigue after an Entyvio® Infusion Treatment, so planning a lighter schedule for the remainder of the day is helpful. If your clinician orders pre-medications, our staff will administer them before the session begins. Visit our Infusion Center page to learn more about our clinical setting and available amenities.

Choosing a Comfortable Setting for Entyvio® Infusion Treatment

Many patients choose TwelveStone for a stable and predictable care environment during long-term biologic therapy. Shifting from a high-volume hospital to a private outpatient suite reduces the clinical stress of recurring medical appointments. Our regional locations provide a consistent routine designed for patient comfort.

Amenities for a Consistent Routine

  • Private suites for quiet and personal space
  • Heated recliners and individual televisions
  • High-speed Wi-Fi and complimentary refreshments
  • Space for a guest chair in every room

Licensed nurses and pharmacists manage every administration to ensure clinical safety and precise monitoring. This specialized focus on complex medications provides high-level expertise within a relaxed environment.

Our supportive care model is personal and respectful, including optional spiritual support. We coordinate with your gastroenterologist to manage scheduling and insurance details for your treatment. Establishing this routine early ensures your therapy remains uninterrupted.

Contact TwelveStone to coordinate your enrollment or ask about preparing for your first visit.

How the Entyvio® Referral and Scheduling Process Works

TwelveStone manages the administrative logistics of Entyvio® to reduce the workload for gastroenterology offices. Our intake team handles the transition from the clinic to the infusion suite. We manage clinical requirements and payer hurdles to ensure treatment begins without delay.

  1. Order Submission: The provider sends the referral and clinical documentation to our intake department.
  2. Benefits Verification: We manage prior authorizations and verify insurance coverage to prevent billing surprises.
  3. Patient Outreach: We contact the patient directly to coordinate the session and provide arrival instructions.
  4. Clinical Reporting: We provide the referring office with a treatment summary for clinical continuity.

Insurance coverage for biologics varies by payer. TwelveStone helps patients understand their benefits and potential out-of-pocket costs before the first appointment. This transparency helps families plan for long-term care while letting specialists focus on clinical outcomes.

Refer a Patient

Frequently Asked Questions About Entyvio® Therapy

The following information addresses common questions regarding the administration and logistics of biologic therapy for ulcerative colitis and Crohn’s disease. Clinical decisions and treatment plans are always determined by your gastroenterologist.

Entyvio is approved for the treatment of moderate to severe Crohn’s disease and ulcerative colitis in adults who have not responded well to other medications. It works by targeting inflammation in the gastrointestinal tract while minimizing systemic immune suppression.

The actual medication infusion commonly takes approximately 30 minutes to complete. However, patients should plan for a longer total appointment time to account for clinical check-in, the initiation of the IV line, and a brief observation period after the session. Total time at the center varies based on individual clinical needs and the specific protocols required for your first or subsequent visits.

Most patients follow a standardized induction schedule with infusions at Week 0, Week 2, and Week 6 to establish the medication in the system. After this initial phase, maintenance treatments typically occur every eight weeks. Your prescribing physician may adjust this frequency based on your specific condition and how your body responds to the therapy over time.

Coverage for biologic infusions varies significantly depending on your specific insurance plan and provider benefits. TwelveStone Health Partners assists patients with the benefits verification and prior authorization process to clarify coverage before the first appointment. Patients may be responsible for copays or coinsurance, and our financial team can provide an estimate of expected costs prior to starting treatment.

Clinical staff monitors patients closely during the entire infusion process and for a period immediately following the session. You should alert your nurse if you experience any new symptoms, such as a rash, shortness of breath, or itching, which may indicate a hypersensitivity reaction. Reporting any changes in how you feel allows the clinical team to respond quickly and ensure your safety.

Many patients find they can drive themselves home and resume their regular daily routine immediately after their appointment. However, some individuals experience fatigue following biologic therapy, so it is often helpful to plan a lighter schedule for your first few visits. If your physician orders pre-medications like antihistamines, these may cause drowsiness and could affect your ability to drive.

Some patients may have the option to transition from IV infusions to a self-injection maintenance pen if their gastroenterologist determines it is clinically appropriate. This change typically occurs only after the initial induction phase is completed via IV administration. The route of administration remains a medical decision made by your provider and involves coordination with a specialty pharmacy for medication delivery.