TwelveStone Health Partners provides clinic-based Leqvio® treatment across the Southeast. Leqvio® (inclisiran) is a prescription medication used to lower LDL (“bad”) cholesterol in patients who need additional support beyond diet and statins.

To get started with Leqvio® treatment, complete the Leqvio® Order Form and submit it to our team.

35+ Years of Clinical Excellence

Leqvio is administered as a quick subcutaneous injection during a clinic visit—not a long IV infusion. Physicians can refer eligible patients directly to our centers, and patients can request scheduling support to begin treatment.

Schedule an appointment or submit a patient referral through our contact page.

Professional Care You Can Trust

  • 35+ Year Heritage: Roots dating back over three decades as a trusted regional provider.
  • 30+ Infusion Centers: Accessible locations throughout Tennessee, Kentucky, Georgia, Mississippi, and Virginia.
  • PharmD-Led Care: Pharmacists and specialized nurses manage all safety protocols and medication administration.
  • Insurance Support: Comprehensive assistance with benefit verification and prior authorizations to simplify enrollment.
  • Private Treatment Suites: Individual rooms with recliners and Wi-Fi for a comfortable patient experience.

Understanding Leqvio® (inclisiran) for LDL Reduction

Leqvio (inclisiran) is a prescription medicine used with diet and exercise to reduce LDL-C, or bad cholesterol, in appropriate patients. This medication helps the body lower cholesterol levels by decreasing a liver signal involved in the natural cholesterol regulation process. 

Unlike daily oral medications, a healthcare professional administers this treatment twice a year after the initial starter doses. Leqvio® Infusion Treatment is often used to treat specific patient populations who require additional intervention to manage their cardiovascular health:

  • Adults with persistent high cholesterol
  • Patients with hypercholesterolemia, including heterozygous familial hypercholesterolemia (HeFH)
  • Individuals at elevated cardiovascular risk who need additional LDL lowering as determined by their clinician

Some patients consider clinic-based therapies when they cannot reach goals with lifestyle changes and standard medications or have difficulty staying on frequent dosing regimens. This specialized approach ensures patients receive consistent care without the burden of a daily pill schedule.

Only a prescribing clinician can determine if Leqvio is appropriate for your medical history. Our clinical staff at TwelveStone coordinates closely with your cardiologist or primary physician to handle the administrative details and ensure a seamless transition into our specialized care environment. This partnership allows you to focus on your health while we manage the requirements of your treatment plan.

Professional Administration and Scheduling for Leqvio Treatment

TwelveStone clinical staff provide a professional experience for patients receiving Leqvio® Infusion Treatment. This medication is administered as a subcutaneous injection rather than a traditional IV drip. This eliminates the need for a catheter or the long-duration infusion sessions common with other therapies.

The treatment follows a standard clinical cadence. After the initial dose, patients return for a second dose three months later. Maintenance injections typically occur every six months thereafter, unless a prescriber directs otherwise. This predictable schedule allows for easy planning around your normal routine.

The Appointment Process

Each visit to our infusion center follows a structured protocol. While individual timing varies, most appointments are completed within 30 to 60 minutes.

  1. Check-in and a brief clinical assessment by a nurse.
  2. Administration of the injection by a trained professional.
  3. A short observation period to monitor for minor side effects.
  4. Discharge and scheduling of the next maintenance visit.

Our staff handles all clinical documentation and coordinates timing directly with referring offices to keep records current. This oversight ensures therapy stays on track while reducing the administrative burden for providers. TwelveStone also provides dedicated support for navigating insurance coverage to ensure consistent access to care throughout your treatment journey.

Streamlined Referral and Patient Coordination for Cholesterol Therapy

TwelveStone Health Partners serves as a regional site of care for Leqvio® Infusion Treatment and other clinic-administered cholesterol therapies. With more than 30 locations across Tennessee, Georgia, Kentucky, Mississippi, and Virginia, our Southeast footprint offers a professional outpatient alternative to traditional hospital departments. 

Each center features spacious private suites where licensed nurses manage medication administration and patient monitoring in a controlled, supportive environment. This specialized model provides patients with dedicated coordination and a personalized experience that prioritizes clinical safety and geographic convenience.

The referral and scheduling workflow functions as a direct extension of cardiology and primary care offices to simplify the patient journey. Once a clinician submits a referral or treatment order, TwelveStone manages the benefits verification and assists with necessary prior authorization steps to clarify coverage. 

After resolving these administrative requirements, care coordinators contact the patient directly to schedule their appointment at the nearest center. We provide regular updates to referring providers regarding patient adherence, injection completion, and ongoing treatment status. 

To get started, refer a patient or request an appointment through our contact page.

Common Questions Regarding Leqvio Treatment

After the first dose, a second injection is given approximately three months later. Following these initial starter doses, maintenance injections occur typically every six months. Your prescribing clinician determines the exact schedule based on your clinical response and cholesterol management goals. Consistency with this dosing schedule is essential for maintaining the medication’s effectiveness in lowering LDL cholesterol levels over time.

Patients should generally plan for a 30 to 60 minute visit when visiting our centers for this treatment. This window accounts for the standard check-in process, a brief clinical assessment by a nurse, the administration of the injection, and a period of professional observation. While the injection itself is quick, the monitoring period ensures patient safety and allows staff to address any immediate questions before discharge.

Leqvio is a subcutaneous injection administered by a healthcare professional into the abdomen, thigh, or upper arm. It is not an intravenous (IV) infusion, meaning it does not require a needle to remain in a vein for an extended period or the use of an infusion pump. This delivery method is one reason why these appointments are significantly shorter than traditional IV therapies used for other chronic conditions.

Coverage depends on your specific insurance provider, though Leqvio is widely covered by many commercial plans and Medicare. Because a professional must administer the medication in a clinical environment, it is frequently processed under your medical insurance benefit rather than your pharmacy plan. TwelveStone clinical coordinators perform a thorough benefits verification for every patient and help manage the prior authorization steps required by many payers.

Our clinical staff focuses on monitoring for immediate injection-site reactions, such as localized redness, itching, or swelling. These are the most frequently reported side effects and are usually mild in nature. We follow standardized observation protocols to ensure you are comfortable before leaving the suite. Patients receive clear instructions on when to contact their prescribing physician if they notice any unusual symptoms or persistent discomfort following their visit.

Provider offices should provide basic patient demographics, the relevant diagnosis code for high cholesterol or heart disease, and a signed medication order. Including recent lab results can also help expedite the benefits verification process with certain insurance carriers. Our intake specialists guide the referring office through any missing documentation to ensure there are no delays in beginning the patient’s treatment plan.

If you have additional questions about starting your treatment or managing a referral, contact us. Our team is available to provide the necessary information and support.